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論文publications

主要論文

Yoshida T, Ishidome T, Hanayama R. High purity isolation and sensitive quantification of extracellular vesicles using affinity to TIM4.
Curr Protoc Cell Biol. in press (2017)

Ishidome T, Yoshida T, Hanayama R. Induction of live cell phagocytosis by a specific combination of inflammatory stimuli.
EBioMedicine. 22:89-99 (2017) link 解説

Matsuzaki K, Fujita K, Jingushi K, Kawashima A, Ujike T, Nagahara A, Ueda Y, Tanigawa G, Yoshioka I, Ueda K, Hanayama R, Uemura M, Miyagawa Y, Tsujikawa K, Nonomura N. MiR-21-5p in urinary extracellular vesicles is a novel biomarker of urothelial carcinoma.
Oncotarget. 8(15):24668-78 (2017) link

Nakai Y, Yoshida T, Diez D, Miyatake Y, Nishibu T, Imawaka N, Naruse K, Sadamura Y, Hanayama R. A novel affinity-based method for the isolation of highly purified extracellular vesicles.
Scientific Reports. 6:33935 (2016) link 解説

Song J and Hanayama R. Mechanisms of lysosomal exocytosis by immune cells.
Chronic Inflammation. Miyasaka M. and Takatsu K. eds. (Springer) 369-375 (2016) link

Bahrini I, Song J, Diez D, Hanayama R. Neuronal exosomes facilitate synaptic pruning by up-regulating complement factors in microglia.
Scientific Reports. 5:7989 (2015) link 解説

Hanayama R
.
Autoimmune diseases and the role of MFG-E8.
MFG-E8 and Inflammation. Wang P. ed. (Springer) 97-117 (2014) link

Toda S, Hanayama R, Nagata S.
Two-step engulfment of apoptotic cells.

Mol Cell Biol. 32(1):118-25 (2012) link


Greer PL*, Hanayama R* (*co-first authors), Bloodgood BL, Mardinly AR, Lipton DM, Flavell
SW, Kim TK, Griffith EC, Waldon Z, Maehr R, Ploegh HL, Chowdfury S, Worley PF, Steen J, Greenberg ME. The Angelman Syndrome protein Ube3A regulates synapse development by ubiquitinating Arc.
Cell. 140(5):704-16 (2010) link

Nagata S, Hanayama R, Kawane K. Autoimmunity and the clearance of dead cells.
Cell. 140(5):619-30(2010link

Hanayama R, Miyanishi M, Yamaguchi H, Suzuki J, Nagata S. Engulfment of apoptotic cells and its physiological roles.
Cell Death. Melino G. and Vaux D. eds. (Wiley) 165-75(2010)link

Witasp E, Uthaisang W, Elenstrom-Magnusson C, Hanayama R, Tanaka M, Nagata S, Orrenius S, Fadeel B. Bridge over troubled water: milk fat globule epidermal growth factor 8 promotes human monocyte-derived macrophage clearance of non-blebbing phosphatidylserine-positive target cells.
Cell Death Differ. 14(5):1063-5 (2007) link

Hanayama R, Miyasaka K, Nakaya M, Nagata S. MFG-E8 dependent clearance of apoptotic cells, and autoimmunity caused by its failure.
Curr Dir Autoimmun. 9:162-72(2006)link

Nakaya M, Tanaka M, Okabe Y, Hanayama R, Nagata S. Opposite effects of Rho family GTPases on engulfment of apoptotic cells by macrophages.
J Biol Chem. 281(13):8836-42 (2006) link

Hanayama R and Nagata S. Impaired involution of mammary glands in the absence of milk fat globule EGF factor 8.
Proc Natl Acad Sci USA. 102(46):16886-91 (2005) link

Asano K, Miwa M, Miwa K, Hanayama R, Nagase H, Nagata S, Tanaka M. Masking of phosphatidylserine inhibits apoptotic cell engulfment and induces auto-antibody production in mice.
J Exp Med. 200(4):459-67 (2004) link

Hanayama R, Tanaka M, Miyasaka K, Aozasa K, Koike M, Uchiyama Y, Nagata S. Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice.
Science. 304(5674):1147-50 (2004) link 解説

Miyasaka K, Hanayama R, Tanaka M, Nagata S. Expression of MFG-E8 in bone marrow derived immature dendritic cells for engulfment of apoptotic cells.
Eur J Immunol. 34(5):1414-22 (2004) link

Hanayama R, Tanaka M, Miwa K, Nagata S. Expression of developmental endothelial locus-1 in a subset of macrophages for engulfment of apoptotic cells.
J Immunol. 172(6):3876-82. (2004) link

Tada K, Tanaka M, Hanayama R, Miwa K, Shinohara A, Iwamatsu A, Nagata S. Tethering of apoptotic cells to phagocytes through binding of CD47 to Src homology 2 domain-bearing protein tyrosine phosphatase substrate-1.
J Immunol. 171(11):5718-26. (2003) link

Hanayama R, Tanaka M, Miwa K, Shinohara A, Iwamatsu A, Nagata S. Identification of a factor that links apoptotic cells to phagocytes.
Nature. 417(6885):182-7. (2002) link 解説

Katsuya T, Sato N, Asai T, Fukuda M, Takiuchi S, Fu Y, Hanayama R, Moriguchi A, Rakugi H, Higaki J, Ogihara T. Association of polymorphism in the promoter region of the apolipoprotein E gene with diastolic blood pressure in normotensive Japanese.
Hypertens Res. 23(3):271-5. (2000) link

Matsumoto A, Hanayama R, Nakamura M, Suzuki K, Fujii J, Tatsumi H, Taniguchi N. A high expression of heme oxygenase-1 in the liver of LEC rats at the stage of hepatoma: possible implication of induction in uninvolved tissue.
Free Radic Res. 28(4):383-91. (1998) link